Sacyl Pharmaceuticals
$100,000 Awarded January 2023 |
Sacyl PharmaceuticalsNew York, NY
About
Sacyl Pharmaceuticals, Inc. is working towards innovative contraceptive solutions, leveraging the genetically and pharmacologically validated contraceptive target soluble adenylyl cyclase (sAC; ADCY10) into on-demand options for men. Our Grant
MCI’s support facilitates the development of novel sAC inhibitors as on-demand contraceptives for men by optimizing the safety and efficacy of new compounds. These steps are crucial to overcome the high bar that will be required of any new contraceptive product. |
Publications
Miller, M., Rossetti, T., Ferreira, J., Ghanem, L., Balbach, M., Kaur, N., Levin, L. R., Buck, J., Kehr, M., Coquille, S., van den Heuvel, J., Steegborn, C., Fushimi, M., Finkin-Groner, E., Myers, R. W., Kargman, S., Liverton, N. J., Huggins, D. J., & Meinke, P. T. (2022). Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates. Journal of medicinal chemistry, 65(22), 15208–15226. https://doi.org/10.1021/acs.jmedchem.2c01133
Rossetti, T., Ferreira, J., Ghanem, L., Buck, H., Steegborn, C., Myers, R. W., Meinke, P. T., Levin, L. R., & Buck, J. (2022). Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential. Frontiers in physiology, 13, 1013845. https://doi.org/10.3389/fphys.2022.1013845
Miller, M., Rossetti, T., Ferreira, J., Ghanem, L., Balbach, M., Kaur, N., Levin, L. R., Buck, J., Kehr, M., Coquille, S., van den Heuvel, J., Steegborn, C., Fushimi, M., Finkin-Groner, E., Myers, R. W., Kargman, S., Liverton, N. J., Huggins, D. J., & Meinke, P. T. (2022). Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates. Journal of medicinal chemistry, 65(22), 15208–15226. https://doi.org/10.1021/acs.jmedchem.2c01133
Rossetti, T., Ferreira, J., Ghanem, L., Buck, H., Steegborn, C., Myers, R. W., Meinke, P. T., Levin, L. R., & Buck, J. (2022). Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential. Frontiers in physiology, 13, 1013845. https://doi.org/10.3389/fphys.2022.1013845
